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2022
Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia and solid tumor metastasis
Science Translational Medicine
10.1126/scitranslmed.abm6391
Grigoryan G, Zacharaki D, Balhuizen A, Côme CRM, Garcia Garcia A, Hidalgo Gil D, Frank A, Aaltonen K, Mañas A, Esfandyari J, Kalantari N, Kjellman P, Prithiviraj S, Bexell D, Bourgine PE
Fast and standardized generation of human mini-bones by a custom-designed human mesenchymal cell line. Superior engraftment of human cord blood hematopoietic cells and primary acute myeloid leukemia samples compared to mouse bones.
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