Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches

PNAS

10.1073/pnas.2114227118

García-García A, Klein T, Born G, Hilpert M, Scherberich A, Lengerke C, Skoda RC, Bourgine PE, Martin I

3D osteoblastic niche can sustain malignant CD34+ cells from AML and myeloproliferative neoplasm patients for up to 3 weeks, mimicking the spatial distribution found in native BM tissue.

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