Bourgine PE. Springer Reference book series: "Biomedical Engineering - Tissue Engineering and Regeneration" Abstract: This series Tissue Engineering consists of comprehensive reference texts encompassing the biological basis of tissue regeneration, basic principles of tissue engineering and the current state-of-the-art in tissue engineering of
Bourgine PE, Klein T, Paczulla AM, Shimizu T, Kunz L, Kokkaliaris KD, Coutu DL, Lengerke C, Skoda R, Schroeder T, Martin I. Proceedings of the National Academy of Science USA, 2018. Abstact: In adults, human hematopoietic stem and progenitor cells (HSPCs) reside in
Bourgine PE, Martin I, Schroeder T. Cell Stem Cell, 2018. Abstract Recent advances in engineering complex organs in vitro inspire the development of human bone marrow equivalents to foster scientific discovery and innovative therapeutics. Here, we discuss challenges in generating relevant human bone marrow proxies, potential design principles, and future directions. Full article
Loeffler D, Wang W, Hopf A, Hilsenbeck O, Bourgine PE, Rudolf F, Martin I, Schroeder T. Blood, 2018. Abstract: Keeping track of individual cell identifications is imperative to the study of dynamic single cell behavior over time. Highly motile hematopoietic stem and progenitor
Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H Experimental hematology, 2018. Abstract: Hematopoietic stem cells (HSCs) are maintained in a specialized bone marrow (BM) environment, the so-called HSC niche, that provides pivotal factors for their maintenance. Although the cellular and
Haumer A, Bourgine PE, Occheta P, Tasso R, Martin I. Advanced Drug Delivery Review, 2018. Abstract: Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological
Bourgine PE, Gaudiello E, Pippenger B, Jaquiery C, Klein T, Pigeot S, Todorov Jr A, Feliciano S, Banfi S, Martin I. Advanced Functional Materials, 2017. Abstract: Engineered and decellularized extracellular matrices (ECM) are receiving increasing interest in regenerative medicine as materials capable to
Fat-derived stromal vascular fraction cells enhance the bone forming capacity of devitalized engineered hypertrophic cartilage matrix.
Todorov A, Kreutz M, Haumer A, Scotti C, Barbero A, Bourgine PE, Scherberich A, Jaquiery C, Martin I. Stem Cells Translational Medicine, 2016. Abstract: Engineered and devitalized hypertrophic cartilage (HC) has been proposed as bone substitute material, potentially combining the features of osteoinductivity,
Engineered Decellularized Matrices to instruct osteoprogenitor cells into bone regeneration processes.
Papadimitropoulos A, Scotti C, Bourgine PE, Scherberich A, Martin I. Bone, 2015. Abstract: Despite the significant progress in the field of bone tissue engineering, cell-based products have not yet reached the stage of clinical adoption. This is due to the uncertain advantages
Bourgine PE, Scotti C, Pigeot S, Tchang LA, Todorov A, Ivan Martin. Proceedings of the National Academy of Science USA, 2014. Article: The role of cell-free extracellular matrix (ECM) in triggering tissue and organ regeneration has gained increased recognition, yet current approaches are