14-03-2025
The CTO Workshop during UniStem Day 2025!
On March 14th, Aurélie, Sara and Alex organized a Workshop as part of UniStem Day 2025, to show high school students how to assemble our bioreactor. The three groups of students showed high interest for the activity and they all did a great job!
11-03-2025
Laura is starting her PhD at CTO!
After completing her Master's thesis in our group, Laura has now started as a PhD student at CTO. Her research will focus on studying the immunoregulatory capacities of the human bone marrow niche and their impact on the efficacy of cellular immunotherapies against AML. We wish you the best of luck for this new adventure with us!
19-02-2025
CTO lab at the ESH Workshop in London!
Sara, Camille, Aurélie and Laura had the opportunity to present their work during the poster session of the '5th Scientific Workshop: the Haematological Tumour Microenvironment and its Therapeutic Targeting' organized by the European School of Haematology on the 17th and 18th of February!
27-11-2024
OssiGel is highlighted in the IVA top100 list
Our OssiGel technology appears in the IVA list, highlighting the top 100 research projects with commercialization potential!
01-10-2024
Welcome to CTO Alex!
Alex just started his master internship in the CTO lab. He is an enthusiastic scientist from the United Kingdom with a bachelor’s degree in biology from the University of Exeter and a master’s degree in biomedicine from Lund Universitet. He has a broad interest in haematology, and he will take part of a project studying the role of the bone marrow niche-mediated drug resistance in acute myeloid leukaemia.
01-10-2024
CTO lab at the Lund Stem Cell Center Annual Retreat!
Aurélie and Laura had the opportunity to present their work during the poster session of the LSCC Annual Retreat in Båstad on the 1st of October!
01-09-2024
Welcome to CTO Sacha!
Sacha is joining the CTO lab for her master internship. She is currently pursuing the second year of her Master in Biomedical Engineering at the University of Twente in the Netherlands. She will stay until the end of January and her work will focus on the influence of a sepcific long non-coding RNA within endochodral ossification. Welcome Sacha!
12-07-2024
The CTO lab attending ISSCR 2024 in Hamburg!
Paul, Alejandro and David had the opportunity to present the ongoing projects in the lab during the ISSCR poster sessions on July 11th and 12th.
11-06-2024
Congrats on your Master thesis defense Laura!
This week, Laura successfully defended her Master thesis named ``Identifying phenotypic markers predictive for mesenchymal chondrogenic capacity``. Well done Laura!
05-06-2024
Goodbye Alexandra!
Today Alexandra finished her internship in our lab. She has been working on assessing the hematopoietic protective effect of the bone marrow niche. Best of lucks in the future Alexandra!
30-05-2024
Congrats on your PhD defense Steven!
On May 30th Steven defended his PhD entitled ``Standardization strategies for characterizing and manipulating the human bone marrow microenvironment``. Dr Olaia Naveiras from the University of Lausanne was his opponent.
Congratulations for your success!
15-05-2024
First nailing of PhD at the CTO!
Steven nailed his thesis at the BMC B11 cafeteria this week. Tradition obliges, and the nail went into the wooden slab for the first time at CTO! This event marks the final countdown for his thesis defense, to take place on May 30th. Attracted by the prospect of prosecco and refreshments, fellow lab mates and friends joined in for the occasion!
01-03-2024
Welcome to the CTO lab Camille!
Camille is a postdoctoral researcher that joined our lab in March. She graduated from a Master's in Cellular Signaling in Cancer from the University of Burgundy (Dijon, France) in 2019. Then, her PhD project focused on the role of an epigenetic factor on the inflammatory signaling pathways in acute myeloid leukemia. At the Bourgine lab, she aims to better understand the molecular mechanisms occuring during the interaction between mesenchymal stromal cells and AML cells using our mini-bone technology.
16-02-2024
Congratulations on your half-time PhD defense David!
David successfully defended his PhD projects' progress in front of his half-time committee and received constructive feedback from Göran Karlsson and Nicholas Leigh towards the completion of his PhD. Congrats again David!
15-01-2024
Warm welcome Laura!
This January Laura joined the CTO team to conduct her Master's thesis. She comes from Barcelona and she is currently studying a Master's in Genetics in Université Paris Cité in France. During her thesis, Laura will be working on the identification of new predictive markers to improve the chondrogenic and osteogenic quality of our MSOD-B cell line. In parallel, she will also be involved in the in vivo reprogramming of a leukemia cell line in humanized ossicles.
22-12-2023
New PoC grant from SciLifeLab’s and Knut and Alice Wallenberg Foundation’s program!
SciLifeLab’s and Knut and Alice Wallenberg Foundation’s program on Proof of Concept grants awarded our team with one out of ten prestigious grants. This will pivot our project ``Bioengineering human mini-bones as personalized therapeutic-testing platform`` to new exciting directions! The pitching team (left to right): Paul Bourgine, Dimitra Zacharaki and Alejandro Garcia Garcia.
14-12-2023
Paul awarded a Vinnova Emerging Technology Solutions grant!
Paul received a Swedish Vinnova Emerging Technology Solutions Stage 1 grant to develop the project ``OssiGel: the formation of human mini-bones as personalized drug-testing platform``. Congrats Paul!!!
10-12-2023
Welcome Sara to the CTO team!
This December we welcomed to our team Sara, our new postdoctoral research member! A few words from Sara:
``I studied Biology at the University of Leon and conducted my Master’s in Regenerative Biomedicine at the University of Granada, both in Spain. I have always been very interested in stem cells and tissue regeneration. This led to my first assignment as a research assistant in London, and then had the opportunity to complete my PhD studies at the Imperial College London in Cristina Lo Celso's group, where I studied how acute myeloid leukaemia and chemotherapy disrupt the bone marrow niche and how this remodelling affects haematopoietic stem cells.
I recently started my first post doc at the Cell, Tissue and Organ engineering laboratory, led by Paul Bourgine. In my project I will use the human mini-bone technology developed in the lab to better understand how a novel type of immunotherapy, CAR T cells, function in a human microenvironment in the context of leukaemia.
Outside the lab, I love coffee time, exploring new places, and enjoying any kind of art!``
06-12-2023
Paul awarded a prestigious Cancerfonden grant!
Hurray! Paul is granted a Cancerfonden grant that will finance our project titled ``Personalized modeling of AML disorders by engineering of patient-derived mini-bone organs``.
04-12-2023
David is taking part on the ISSCR international simposium
This week David is in Vienna participating in the ISSCR international simposium taking part in the Hofburg in Vienna. This years topic is on unveiling the principles of development. He is presenting his new project on the study of the chromatin landscape of the endochondral ossification process using the ossicle model and single cell multiomics.
11-10-2023
Today Dimitra presented her work on the SSC next generation seminar series
Dimitra Zacharaki presented her work using the humanised ossicle model for the establishment of autologous AML niches.
Congratulations Dimitra on the good work!
29-09-2023
Sujeeth presented his work at the WCMM friday club
Today Sujeeth took part in the WCMM friday club. He presented his work on the generation of tissue engineered grafts for bone and cartilage regeneration and their potential immunogenicity
22-09-2023
Congrats Ani for winning the award to paper of the year from the Lund SCC!
Ani Grigoryan won the prize to best paper of the year 2022 in the Lund SCC for her paper published last year in science translational medicine where we showed the capabilities of the ossicle model for the study of different tumor metastasis. Read more about it on our publications page!
21-09-23
We are at the Lund SCC annual retreat!
Today the CTO team joined the annual Lund Stem Cell Centre retreat. During our time there Sujeeth and Steven shared the latest advancements in their projects in the development of standardized grafts for cartilage regeneration and the mitochondria transfer between niche and hematopoietic cells respectively.
We also had the chance to reunite with Ani, the first CTO postdoc to leave the lab to establish her own at Ulm University where she researches how aging affects the bone marrow niche. Tomorrow she will also be presenting her paper on the use of the ossicle model as a platform to study tumor metastasis, as a candidate for best paper of the year.
13-09-23
Alejandro shared his research project in the next gen seminar series
Today Alejandro presented his advancements on the generation of decellularized cartilage grafts for bone regeneration. This research pushes tissue engineering towards a paradigm shift towards standardized cell sources and the application in different bone injury models.
19-10-2020
Welcome Medea to the CTO team!
This week Medea, from the University of Applied Sciences Krems in Austria joined the CTO lab.
During her time with us she will join Dimitra for the characterization of mesenchymal stromal cells from leukemic patients in humanized ossicles.
05-09-2023
The CTO team participates to the ESB 2023 conference
This week Alejandro and Paul are proudly representing the CTO team in the European Society for Biomaterials conference 2023.
During these days we will be sharing our research on the immunogenicity and regenerative potential of hypertrophic cartilage grafts.
26-06-2023
Congratulations Lucille for your Master Defense
Lucille joined the CTO lab from France, during her stay in the CTO lab she worked with David researching vascular associated MSC populations.
14-06-2023
Congratulations Patrizia on your Master Thesis defense
Patrizia joined the CTO lab from Uppsala university back in January. During her time here she worked mainly on quality assessments on different MSOD-B batches. Now she will be looking for her next step in her career abroad.
09-06-2023
Congratulations Tommi for your master defense
Today we celebrate Tommi's master thesis defense. During his time as part of the CTO team he has been studying how premineraliaztion of cartilage grafts can enhance bone regeneration.
Now he is moving on to developing his career as a medical doctor.
Best wishes in your future Tommi.
19-04-2023
Closing the 2023 LU SCC conference
This week the CTO team joined the 2023 Lund Stem Cell Centre conference celebrating its 20 anniversary.
During the last 3 days, we had the chance to share our latest advancements in our research as well as diving into the great research of the center and the amazing invited researchers with international profiles.
Congratulations to everyone who assisted and to the team that made it happen.
12-04-23
WCMM Research day
Today we participated in the 2023 edition of the WCMM research day. All the WCMM researchers came together to share their cutting edge research. In his presentation, Steven shared his progress and accomplishments throughout his Ph.D. and grabbed the price for the best presentation of the day.
28-02-2023
Good Bye Yuan
This week was the last one for Yuan in our lab after 2 years working as a bioinformatician across different projects. Now she is continuing her career in the National Bioinformatics Infrastructure (NBIS) from Lund.
Best of wishes in your career!
13-02-2023
Welcome to Aurelie
We welcome Aurelie Baudet to the lab!
In the mini-bones team, she will be focusing on therapy escape in AML, characterizing the response of patient-derived xenografts (conventional and ossicles) to treatment and comparing it to the evolution of the disease in the patient. By tackling the mechanism behind disease relapse, we aim at developing tools predictive of patient’s response to treatment.
26-01-2023
Steven presented a recapitulation of his PhD projects in our seminar series.
Today Steven gave a presentation about the new work done on the bioreactor and the mitochondria transfer at the first BMC C12 seminar. Very interactive presentation with plenty of relevant questions. Thanks to Anders Malmström for giving us the opportunity to present our work!
01-09-2022
Welcome Patrizia
She has a bachelor's degree in Molecular Medicine from the University of Göttingen in Germany. Since the last two years she has been studying her master’s studies in Molecular Medicine at Uppsala University. Before coming to Lund, she was studying for 6 months at Ghent University, as part of the Erasmus program, to take courses in tissue engineering and regenerative medicine. During her master thesis in our lab, she will investigate the batch-to-batch variation of the MSOD-B cell line and the impact on the quality of 3D-engineered cartilage tissues.