Cell Stem Cell, 2018. Bourgine PE, Martin I, Schroeder T. Abstract Recent advances in engineering complex organs in vitro inspire the development of human bone marrow equivalents to foster scientific discovery and innovative therapeutics. Here, we discuss challenges in generating relevant human bone marrow proxies, potential design principles, and future directions. Full article
Blood, 2018. Loeffler D, Wang W, Hopf A, Hilsenbeck O, Bourgine PE, Rudolf F, Martin I, Schroeder T. Abstract: Keeping track of individual cell identifications is imperative to the study of dynamic single cell behavior over time. Highly motile hematopoietic stem and progenitor
Experimental hematology, 2018. Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H Abstract: Hematopoietic stem cells (HSCs) are maintained in a specialized bone marrow (BM) environment, the so-called HSC niche, that provides pivotal factors for their maintenance. Although the cellular and
Advanced Drug Delivery Review, 2018. Haumer A, Bourgine PE, Occheta P, Tasso R, Martin I. Abstract: Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex interplay of cellular and molecular processes, which tightly involve the immune system. Pathological
Advanced Functional Materials, 2017. Bourgine PE, Gaudiello E, Pippenger B, Jaquiery C, Klein T, Pigeot S, Todorov Jr A, Feliciano S, Banfi S, Martin I. Abstract: Engineered and decellularized extracellular matrices (ECM) are receiving increasing interest in regenerative medicine as materials capable to
Fat-derived stromal vascular fraction cells enhance the bone forming capacity of devitalized engineered hypertrophic cartilage matrix.
Stem Cells Translational Medicine, 2016. Todorov A, Kreutz M, Haumer A, Scotti C, Barbero A, Bourgine PE, Scherberich A, Jaquiery C, Martin I. Abstract: Engineered and devitalized hypertrophic cartilage (HC) has been proposed as bone substitute material, potentially combining the features of osteoinductivity,
Engineered Decellularized Matrices to instruct osteoprogenitor cells into bone regeneration processes.
Bone, 2015. Papadimitropoulos A, Scotti C, Bourgine PE, Scherberich A, Martin I. Abstract: Despite the significant progress in the field of bone tissue engineering, cell-based products have not yet reached the stage of clinical adoption. This is due to the uncertain advantages
Proceedings of the National Academy of Science USA, 2014. Bourgine PE, Scotti C, Pigeot S, Tchang LA, Todorov A, Ivan Martin. Article: The role of cell-free extracellular matrix (ECM) in triggering tissue and organ regeneration has gained increased recognition, yet current approaches are
Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival
Stem Cell Research, 2014. Bourgine PE, Le Magnen C, Geurts J, Scherberich A, Martin I. Abstract: The hTERT-immortalization of human bone marrow-derived Mesenchymal Stromal Cells (hMSCs) was proposed to address availability/standardization issues for experimental or clinical studies, but raised concerns due to possible
Biomaterials, 2013. Bourgine PE, Pippenger BE, Todorov A Jr, Tchang L, Martin I. Abstract Decellularized tissues, native or engineered, are receiving increasing interest in the field of regenerative medicine as scaffolds or implants for tissue and organ repair. The approach, which offers the