Wanna collaborate with us?

We are always interested by highly motivated young scientists at the Master, PhD and Post-doctoral level! Applicants with an international research experience and strong background in molecular biology/immunology/developmental biology/bioengineering are encouraged to apply. You will be most welcome in a young, friendly and dynamic environment. See below positions detailed. Please provide your CV, motivation statement and up to 3 referees at: paul.bourgine @ med.lu.se

GENERAL INFORMATION

The lab: The successful candidates will be part of the novel laboratory for Cell, Tissue and Organ engineering. The laboratory is part of the Wallenberg Centre for Molecular Medicine (WCMM LU), at the Lund Faculty of Medicine (https://www.med.lu.se/english). Focusing on regenerative medicine (regeneration, replacement and repair), WCMM LU is part of a national effort to strengthen Sweden as a world-leading life science nation (https://www.med.lu.se/wcmm).

Our lab aims at deciphering the cellular & molecular mechanisms occurring during phases of bone formation/repair. Using state-of-the-art 3D culture systems, death-inducible human mesenchymal lines and tissue engineering protocols, we focus on studying processes of cartilage/bone/bone marrow establishment in human(ized) contexts. Compiled knowledge will be used for the design of cell-based but cell-free extracellular matrices, to be used as smart-materials for skeletal repair. As such, the lab covers both fundamental and translation research aspects. More information available on our website: www.bourginelab.com

The University: The lab located within the BioMedical Center at the Faculty of Medicine, and is part of Lund University (Sweden). The university was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. Lund University has 42 000 students and 7 400 staff based in Lund, Helsingborg and MalmöThe Faculty of Medicine as part of Lund University is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty’s strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world. Easily accessible via Copenhagen airport (35min), Lund is a dynamic and well-connected city in the heart of the Scandinavian hub.

OPEN POSTDOCTORAL POSITION (#001):

In vivo engineering of human hematopoietic stem cell niches

The position: We are seeking for a candidate with a high and healthy ambition to discover! The successful candidate will hold a postdoctoral position for two years (renewable) funded by an ERC Starting grant. The project will consist in exploiting the human ossicle technology to form molecularly customized niches in mice. Those will be exploited under two axes:

(i) increase the development and functionality of engrafted human hematopoietic cells in human ossicles

(ii) study the engraftment of AML/MDS patient materials and the corresponding impact of the human niche in disease progression

Ideal profile: You possess a PhD degree in biology or equivalent and a strong background in cell and molecular biology applied to mesenchymal stem cells and/or hematopoiesis. You have robust experience in flow cytometry, confocal microscopy techniques, cell culture, animal experimentation. Previous experience on the engineering of humanized mice or on the study of the bone marrow niche in malignant context is a strong asset. Experience in molecular cloning, spatial-transcriptomic or scRNA transcriptomics is a plus.

OPEN POSTDOCTORAL POSITION (#002): Deciphering Human Mesenchymal Stem Cell fate

We are looking for an ambitious and motivated postdoc!

Work assignments: The candidate will decipher the heterogeneity of human Mesenchymal Stromal Cells populations using advanced in vivo models of bone formation. Their phenotype, differentiation potentials and role in the hematopoietic niche will be determined through 3D confocal microscopy and Omics technology (including spatial-transcriptomics).

Ideal profile: You are a freshly graduated PhD looking for a post-doctoral experience to complement your existing skills/knowledge. You possess a strong fundamental background in the cellular/molecular biology of (human) mesenchymal stem/stromals cell and their role in the hematopoietic functions. You are experienced in flow cytometry, confocal microscopy techniques, cell culture, and you are capable of handling animals. An experience in tissue engineering is a plus, as well as knowledge on bone or cartilage tissues. The laboratory will offer you robust training in human cellular biology, engineering of human cells/tissues/organs, as well as in manipulation of 3D culture systems. Desirable skills include an excellent speaking/writing English levels. Experience in molecular cloning, spatial-transcriptomic and sequencing data analysis is a plus.

Qualifications: Appointment to a post-doctoral position requires that the applicant has a PhD, or an international degree deemed equivalent to a PhD, within the subject of the position, completed no more than three years before the last date for applications. Under special circumstances, the doctoral degree can have been completed earlier.