Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches
PNAS, 2021. Andrés García-García, Thibaut Klein, Gordian Born, Morgane Hilpert, Arnaud Scherberich, Claudia Lengerke, Radek C. Skoda, Paul E. Bourgine, Ivan Martin Abstract Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) niches, which remain challenging to explore due to limited in vivo accessibility and constraints with humanized animal models. Several in vitro systems
Manufacturing of Human Tissues as off-the-Shelf Grafts Programmed to Induce Regeneration
Advanced materials, 2021. Pigeot, S., Klein, T., Gullotta, F., Dupard, S. J., Garcia, A., García-García, A., Prithiviraj, S., Lorenzo, P., Filippi, M., Jaquiery, C., Kouba, L., Asnaghi, M. A., Raina, D. B., Dasen, B., Isaksson, H., Önnerfjord, P., Tägil, M., Bondanza, A., Martin, I., Bourgine, P. E. Abstract Design criteria for tissue-engineered materials in regenerative medicine include robust biological effectiveness, off-the-shelf availability,