Congrats on your PhD defense Steven!

On May 30th Steven defended his PhD entitled ``Standardization strategies for characterizing and manipulating the human bone marrow microenvironment``. Dr Olaia Naveiras from the University of Lausanne was his opponent.
Congratulations for your success!


First nailing of PhD at the CTO!

Steven nailed his thesis at the BMC B11 cafeteria this week. Tradition obliges, and the nail went into the wooden slab for the first time at CTO! This event marks the final countdown for his thesis defense, to take place on May 30th. Attracted by the prospect of prosecco and refreshments, fellow lab mates and friends joined in for the occasion!


Welcome to the CTO lab Camille!

Camille is a postdoctoral researcher that joined our lab in March. She graduated from a Master's in Cellular Signaling in Cancer from the University of Burgundy (Dijon, France) in 2019. Then, her PhD project focused on the role of an epigenetic factor on the inflammatory signaling pathways in acute myeloid leukemia. At the Bourgine lab, she aims to better understand the molecular mechanisms occuring during the interaction between mesenchymal stromal cells and AML cells using our mini-bone technology.


Congratulations on your half-time PhD defense David!

David successfully defended his PhD projects' progress in front of his half-time committee and received constructive feedback from Göran Karlsson and Nicholas Leigh towards the completion of his PhD. Congrats again David!


Warm welcome Laura!

This January Laura joined the CTO team to conduct her Master's thesis. She comes from Barcelona and she is currently studying a Master's in Genetics in Université Paris Cité in France. During her thesis, Laura will be working on the identification of new predictive markers to improve the chondrogenic and osteogenic quality of our MSOD-B cell line. In parallel, she will also be involved in the in vivo reprogramming of a leukemia cell line in humanized ossicles.


New PoC grant from SciLifeLab’s and Knut and Alice Wallenberg Foundation’s program!

SciLifeLab’s and Knut and Alice Wallenberg Foundation’s program on Proof of Concept grants awarded our team with one out of ten prestigious grants. This will pivot our project ``Bioengineering human mini-bones as personalized therapeutic-testing platform`` to new exciting directions! The pitching team (left to right): Paul Bourgine, Dimitra Zacharaki and Alejandro Garcia Garcia.


Paul awarded a Vinnova Emerging Technology Solutions grant!

Paul received a Swedish Vinnova Emerging Technology Solutions Stage 1 grant to develop the project ``OssiGel: the formation of human mini-bones as personalized drug-testing platform``. Congrats Paul!!!


Welcome Sara to the CTO team!

This December we welcomed to our team Sara, our new postdoctoral research member! A few words from Sara:
``I studied Biology at the University of Leon and conducted my Master’s in Regenerative Biomedicine at the University of Granada, both in Spain. I have always been very interested in stem cells and tissue regeneration. This led to my first assignment as a research assistant in London, and then had the opportunity to complete my PhD studies at the Imperial College London in Cristina Lo Celso's group, where I studied how acute myeloid leukaemia and chemotherapy disrupt the bone marrow niche and how this remodelling affects haematopoietic stem cells.
I recently started my first post doc at the Cell, Tissue and Organ engineering laboratory, led by Paul Bourgine. In my project I will use the human mini-bone technology developed in the lab to better understand how a novel type of immunotherapy, CAR T cells, function in a human microenvironment in the context of leukaemia.
Outside the lab, I love coffee time, exploring new places, and enjoying any kind of art!``


Paul awarded a prestigious Cancerfonden grant!

Hurray! Paul is granted a Cancerfonden grant that will finance our project titled ``Personalized modeling of AML disorders by engineering of patient-derived mini-bone organs``.


David is taking part on the ISSCR international simposium

This week David is in Vienna participating in the ISSCR international simposium taking part in the Hofburg in Vienna. This years topic is on unveiling the principles of development. He is presenting his new project on the study of the chromatin landscape of the endochondral ossification process using the ossicle model and single cell multiomics.


Today Dimitra presented her work on the SSC next generation seminar series

Dimitra Zacharaki presented her work using the humanised ossicle model for the establishment of autologous AML niches.
Congratulations Dimitra on the good work!


Sujeeth presented his work at the WCMM friday club

Today Sujeeth took part in the WCMM friday club. He presented his work on the generation of tissue engineered grafts for bone and cartilage regeneration and their potential immunogenicity


Congrats Ani for winning the award to paper of the year from the Lund SCC!

Ani Grigoryan won the prize to best paper of the year 2022 in the Lund SCC for her paper published last year in science translational medicine where we showed the capabilities of the ossicle model for the study of different tumor metastasis. Read more about it on our publications page!


We are at the Lund SCC annual retreat!

Today the CTO team joined the annual Lund Stem Cell Centre retreat. During our time there Sujeeth and Steven shared the latest advancements in their projects in the development of standardized grafts for cartilage regeneration and the mitochondria transfer between niche and hematopoietic cells respectively.
We also had the chance to reunite with Ani, the first CTO postdoc to leave the lab to establish her own at Ulm University where she researches how aging affects the bone marrow niche. Tomorrow she will also be presenting her paper on the use of the ossicle model as a platform to study tumor metastasis, as a candidate for best paper of the year.


Alejandro shared his research project in the next gen seminar series

Today Alejandro presented his advancements on the generation of decellularized cartilage grafts for bone regeneration. This research pushes tissue engineering towards a paradigm shift towards standardized cell sources and the application in different bone injury models.


Welcome Medea to the CTO team!

This week Medea, from the University of Applied Sciences Krems in Austria joined the CTO lab.
During her time with us she will join Dimitra for the characterization of mesenchymal stromal cells from leukemic patients in humanized ossicles.


The CTO team participates to the ESB 2023 conference

This week Alejandro and Paul are proudly representing the CTO team in the European Society for Biomaterials conference 2023.
During these days we will be sharing our research on the immunogenicity and regenerative potential of hypertrophic cartilage grafts.


Congratulations Lucille for your Master Defense

Lucille joined the CTO lab from France, during her stay in the CTO lab she worked with David researching vascular associated MSC populations.


Congratulations Patrizia on your Master Thesis defense

Patrizia joined the CTO lab from Uppsala university back in January. During her time here she worked mainly on quality assessments on different MSOD-B batches. Now she will be looking for her next step in her career abroad.


Congratulations Tommi for your master defense

Today we celebrate Tommi's master thesis defense. During his time as part of the CTO team he has been studying how premineraliaztion of cartilage grafts can enhance bone regeneration.
Now he is moving on to developing his career as a medical doctor.
Best wishes in your future Tommi.


Closing the 2023 LU SCC conference

This week the CTO team joined the 2023 Lund Stem Cell Centre conference celebrating its 20 anniversary.
During the last 3 days, we had the chance to share our latest advancements in our research as well as diving into the great research of the center and the amazing invited researchers with international profiles.
Congratulations to everyone who assisted and to the team that made it happen.


WCMM Research day

Today we participated in the 2023 edition of the WCMM research day. All the WCMM researchers came together to share their cutting edge research. In his presentation, Steven shared his progress and accomplishments throughout his Ph.D. and grabbed the price for the best presentation of the day.


Good Bye Yuan

This week was the last one for Yuan in our lab after 2 years working as a bioinformatician across different projects. Now she is continuing her career in the National Bioinformatics Infrastructure (NBIS) from Lund.
Best of wishes in your career!


Welcome to Aurelie

We welcome Aurelie Baudet to the lab!
In the mini-bones team, she will be focusing on therapy escape in AML, characterizing the response of patient-derived xenografts (conventional and ossicles) to treatment and comparing it to the evolution of the disease in the patient. By tackling the mechanism behind disease relapse, we aim at developing tools predictive of patient’s response to treatment.


Steven presented a recapitulation of his PhD projects in our seminar series.

Today Steven gave a presentation about the new work done on the bioreactor and the mitochondria transfer at the first BMC C12 seminar. Very interactive presentation with plenty of relevant questions. Thanks to Anders Malmström for giving us the opportunity to present our work!


Welcome Patrizia

She has a bachelor's degree in Molecular Medicine from the University of Göttingen in Germany. Since the last two years she has been studying her master’s studies in Molecular Medicine at Uppsala University. Before coming to Lund, she was studying for 6 months at Ghent University, as part of the Erasmus program, to take courses in tissue engineering and regenerative medicine. During her master thesis in our lab, she will investigate the batch-to-batch variation of the MSOD-B cell line and the impact on the quality of 3D-engineered cartilage tissues.


Goodbye Joao

Today Joao finished his internship in our lab. He has been working on characterizing the mitochondrial transfer process between MSCs and HSCs, punching forward the project towards publicaiton.
Best of lucks in the future Joao


Last day of Karin in the lab

Karin has been working with us for the last year working on her master thesis project, studying the effect of RUNX2 CRISPR knock outs as part of her master thesis project.
We are incredibly happy of your pass through the lab and we wish you the best on your future career as a researcher!


We have been awarded a new ERC grant

We have been awarded an ERC P.O.C. grant this will impulse the development of our first spin-off product!


Dimitra presented our Ossicle technology to the Stem Cell Center

During the Stem Cell Center retreat Dimitra took the lead at showing all researchers in the center our model and its many advantages.
Congratulations Dimitra for your fantastic job an effort!


Congratulations Dimitra for your new position

Recently Dimitra starter her new position as a research and product development manager. She will take the lead on the early development of the first group spin-off product.


New Leica Stellaris platform

We recently got installed a new Leica Stellaris confocal microscope, this platform has the advantage of super fast acquisition as well as being capable of live cell imaging. It will soon be available for the Stem Cell Center


Goodbye Ani

Today we say goodbye to Ani, she has been working as a post doctoral researcher in the lab for the last 2 years, working on the characterization of the ossicle model for hematopoiesis.
Now she is moving on in her research career as an independent researcher in Ulm university where she will be researching hematopoiesis and aging.


Congratulations Steven for your succesfull half time defense!

Steven had his PhD thesis halftime, very engaging feedback and special thanks to the reviewing committee composed of Niels-Bjarne Woods, Darcy Wagner, and Jonas Larsson.


Welcome Joao to the team

Welcome to Joao from Lisboa.
Joao Joined the lab as a master student to study the mitochondrial transfer mechanisms occuring between human MSCs and HSCs


Welcome Ludovica to the team

Recently Ludovica joined the team. From the university of Turin she joined to work on the study of iPS-MSCs and their potential to develop bone in in-vivo systems